The antibody was purified by affinity chromatography.
Sterility
0.22 μm filtered
Clone
1Y26
Isotype
IgG1
Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Concentration
1.0 mg/mL
Buffer
0.22 μm filtered protein solution is in PBS, pH 7.2.
Handling Advice
Avoid freeze/thaw cycles.
Storage
-20 °C
Storage Comment
Aliquot and store at -20°C.
Target
RPII33
(RNA Polymerase II 33kD Subunit (RPII33))
Alternative Name
RNA Polymerase II RPB3
Target Type
Chemical
Background
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The RNA polymermase II subunit RPB3 is a component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft and is known to be involved in transcription termination.