GZMB antibody (Alexa Fluor 647)

Catalog No. ABIN2657899

The Mouse Monoclonal anti-GZMB antibody has been validated for FACS. It is suitable to detect GZMB in samples from Human and Mouse.

Quick Overview for GZMB antibody (Alexa Fluor 647) (ABIN2657899)

Target: GZMB (Granzyme B (GZMB))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This GZMB antibody is conjugated to Alexa Fluor 647

Application: Flow Cytometry (FACS)

Clone: GB11

Product Details anti-GZMB Antibody (Alexa Fluor 647)

Cross-Reactivity: Rat (Rattus)

Purification: The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C

Target Details for GZMB

Target: GZMB (Granzyme B (GZMB))

Alternative Name: Granzyme B

Background: Granzyme B is a 32 kD serine protease, also known as granzyme-2, serine protease B, CCP1, Asp-ase, and CTLA-1. Granzyme B is abundantly stored in the granules of cytotoxic T lymphocytes and NK cells. Low level of expression has been reported in granulocytes, B cells, and activated dendritic cells. Granzyme B is crucial for rapid induction of cell death and apoptosis through interaction with mannose-6-phosphate receptor.

Pathways: Apoptosis, Caspase Cascade in Apoptosis