JAG2 antibody

Catalog No. ABIN2665211

This anti-JAG2 antibody is a Mouse Monoclonal antibody detecting JAG2 in FACS. Suitable for Human.

Quick Overview for JAG2 antibody (ABIN2665211)

Target: JAG2 (Jagged 2 (JAG2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This JAG2 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: MHJ2-523

Product Details anti-JAG2 Antibody

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG1 kappa, IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for JAG2

Target: JAG2 (Jagged 2 (JAG2))

Alternative Name: Jagged 2

Background: The binding of Notch ligands with their receptors results in the proteolysis of Notch and movement of intracellular portion of Notch into the nucleus. This translocation triggers a series of signaling process. The Notch receptors and their ligands are highly conserved signaling molecules throughout development. They regulate cell fate decision for various cell developments, including myogenesis, neurogenesis, and lymphocyte development. There is growing evidence that signals transmitted through different Notch ligands can differentially affect target cells. The Jagged-2 is one of the several Notch ligands identified. It is a single pass transmembrane protein consisting of a large extracellular N-terminal which includes the DSL (Delta-Serrate-Lag-2) domain, followed by a tandem array of EGF-like repeats (ELRs) and cysteine-rich domain (CRD). Jagged 2 is expressed on lymphoma cells and some other tumor cells. Jagged-2 is reported to be essential for the regulation of spermatogenesis. Notch1/Jagged-2 signaling system plays an important role for male germ cells to differentiate, T cells and B cells to differentiate.

Pathways: Notch Signaling, Sensory Perception of Sound