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P2RX7 antibody
P2RX7
Reactivity: Mouse
FACS
Host: Rat
Monoclonal
1F11
unconjugated
Product Details anti-P2RX7 Antibody
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Target
See all P2RX7 Antibodies
P2RX7
(Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7))
Reactivity
All reactivities for P2RX7 antibodies
Mouse
Host
All hosts for P2RX7 antibodies
Rat
Clonality
All clonalities for P2RX7 antibodies
Monoclonal
Conjugate
All conjugates for P2RX7 antibodies
This P2RX7 antibody is un-conjugated
Application
All applications for P2RX7 antibodies
Flow Cytometry (FACS)
Purification
The antibody was purified by affinity chromatography.
Clone
1F11
Isotype
IgG2b kappa
Top Product
Discover our top product P2RX7 Primary Antibody
Alternatives
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anti-Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) (N-Term) antibody
P2RX7
Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig
WB, IHC
Host: Rabbit
Polyclonal
unconjugated
anti-Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) (AA 136-152), (Extracellular Loop) antibody
P2RX7
Reactivity: Human, Mouse, Rat
WB, IHC, FACS, IF, ICC, LCI
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C.
Target Details for P2RX7
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Target
P2RX7
(Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7))
Alternative Name
P2X7R (P2RX7 Products )
Synonyms
p2xr7 antibody, P2RX7 antibody, P2X7 antibody, AI467586 antibody, P2X(7) antibody, P2X7R antibody, p2x7 antibody, purinergic receptor P2X 7 antibody, purinergic receptor P2X, ligand-gated ion channel, 7 antibody, P2X purinoceptor 7 antibody, P2RX7 antibody, p2rx7 antibody, LOC100458463 antibody, P2rx7 antibody
Background
P2X7R, also known as P2X7 receptor, belongs to the family of ligand-gated ion channel receptors. It is expressed on T cells, B cells, macrophages, and microglia. The receptor opens in the presence of extracellular ATP or NAD, leading to intracellular calcium mobilization. P2X7R activation requires higher concentrations of ATP compared to other P2X receptors. Longer stimulation results in larger pores, allowing passage of larger molecules. Activation of these molecules also leads to mitochondrial and cytoskeletal changes as well as IL-1β maturation and release. Ligation of P2X7 receptor can lead to membrane blebbing and cell death.
Pathways
Regulation of Leukocyte Mediated Immunity , Positive Regulation of Immune Effector Process , Synaptic Vesicle Exocytosis
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