Histone H4 antibody (acetylated, N-Term)

Catalog No. ABIN2668867

Product Details anti-Histone H4 Antibody

Target: Histone H4

Binding Specificity: acetylated, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Histone H4 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Chromatin Immunoprecipitation (ChIP), Dot Blot (DB), Immunocytochemistry (ICC)

Purification: None

Immunogen: This Histone H4 pan-acetylantibody was raised against a peptide containing the amino terminal region of Tetrahymena histone H2A acetylated at multiple lysines. (The immunogen has a high degree of homology to mammalian histone H4, so the antibody recognizes acetylated histone H4 in HeLa extracts).

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice:

Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Storage: -20 °C

Storage Comment: Antibodies in solution can be stored at -20 °C for 2 years.

Expiry Date: 6 months

References for anti-Histone H4 antibody (ABIN2668867)

Kungulovski, Nunna, Thomas, Zanger, Reinhardt, Jeltsch: "Targeted epigenome editing of an endogenous locus with chromatin modifiers is not stably maintained." in: Epigenetics & chromatin, Vol. 8, pp. 12, (2015) (PubMed).

Xiao, Shi, Fan, Zhang, Wu, Lan, Minze, Fu, Ghobrial, Liu, Li: "GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation." in: Nature communications, Vol. 6, pp. 8266, (2015) (PubMed).

Lehmann, Hoffmann, Koch, Ulrich, Schulz, Niegisch: "Histone deacetylase 8 is deregulated in urothelial cancer but not a target for efficient treatment." in: Journal of experimental & clinical cancer research : CR, Vol. 33, pp. 59, (2014) (PubMed).

Li, Wu, Kim, Zhao, Hearn, Zhang, Meistrich, Mills: "Chd5 orchestrates chromatin remodelling during sperm development." in: Nature communications, Vol. 5, pp. 3812, (2014) (PubMed).

Walker, LaFerla, Oddo, Brewer: "Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer's disease." in: Age (Dordrecht, Netherlands), Vol. 35, Issue 3, pp. 519-31, (2013) (PubMed).

Larsson, Ulfhammer, Magnusson, Bergh, Lunke, El-Osta, Medcalf, Svensson, Karlsson, Jern: "Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression." in: PLoS ONE, Vol. 7, Issue 2, pp. e31573, (2012) (PubMed).

Fazzio, Panning: "Condensin complexes regulate mitotic progression and interphase chromatin structure in embryonic stem cells." in: The Journal of cell biology, Vol. 188, Issue 4, pp. 491-503, (2010) (PubMed).

Gray, Pett, Ward, Winder, Stanley, Roberts, Scarpini, Coleman: "In vitro progression of human papillomavirus 16 episome-associated cervical neoplasia displays fundamental similarities to integrant-associated carcinogenesis." in: Cancer research, Vol. 70, Issue 10, pp. 4081-91, (2010) (PubMed).

Target Details for Histone H4

Target: Histone H4

Abstract: Histone H4 Products

Synonyms: hist1h4l antibody, H1ft antibody, Hist4 antibody, Hist4h4 antibody, H4 antibody, X04652 antibody, FO108 antibody, H4/n antibody, H4F2 antibody, H4FN antibody, HIST2H4 antibody, H4C13 antibody, H4C7 antibody, F8N16.2 antibody, F8N16_2 antibody, histone H4 antibody, BcDNA:RH52884 antibody, CG3379 antibody, Dmel\CG3379 antibody, H4r antibody, His4-88CD antibody, His4R antibody, histone cluster 1, H4a L homeolog antibody, histone cluster 1 H4 family member B antibody, histone cluster 2, H4 antibody, histone cluster 2 H4 family member a antibody, histone H4 antibody, Histone H4 replacement antibody, Histone H4 antibody, hist1h4a.L antibody, Hist1h4b antibody, Hist2h4 antibody, HIST2H4A antibody, H4 antibody, H4C14 antibody, HIS4 antibody, HIST2H4 antibody, His4r antibody, his-38 antibody

Molecular Weight: 8 kDa

Gene ID: 121504