Prelamin A (C-Term) antibody
Reactivity: Human
IF, ELISA, WB
Host: Rabbit
Polyclonal
unconjugated
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- Target
- Prelamin A
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Binding Specificity
- C-Term
- Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- Un-conjugated
- Application
- Immunofluorescence (IF), ELISA, Western Blotting (WB)
- Specificity
- Anti prelamin A polyclonal antibody detects fulllength prelamin A which has not yet undergone to proteolytic steps, both in its nonfarnesylated and in its farnesylated form. The farnesylated form of fulllength prelamin A is labelled by antibody with lower efficiency. The antibody does not cross react with mature lamin A.
- Characteristics
- Several laminopathies are characterized by anomalous accumulation of prelamin A. This polyclonal antibody is able to detect full-lenght prelamin A, while it does not recognize either mature lamin A or cleaved prelamin A intermediates.
- Purification
- Polyclonal immunoglobulins purified by protein A affinity chromatography and stabilized with 5% of glycerol.
- Immunogen
- Prelamin A C-terminus peptide
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Supplied in 100 mM sodium citrate, 50 mM Tris and 0.05 % v/v glycerol
- Storage
- 4 °C
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- Target
- Prelamin A
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