PVRL2 antibody

Catalog No. ABIN2688890

Product Details anti-PVRL2 Antibody

Target: PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PVRL2 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Brand: BD Pharmingen™

Characteristics: Reacts with the poliovirus receptor 2 (PRR2) protein. PRR2 is a cell surface molecule homologous to the poliovirus receptor (PVR/CD155). It is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The PRR2 gene encodes for two mRNA isoforms, a short form of 3.0 kb (hPRR2α) and a long form of 4.4 kb (hPRR2δ). Both are widely expressed in human tissues, including hematopoietic cells. PRR2 is also expressed on endothelial cells, at the intercellular junctions of adjacent cells. It has been suggested that PRR2 may play a role in the regulation of hematopoietic/endothelial cell interaction. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of HL-60 cell line analyzed by flow cytometry. Second step staining with Cat. No. 555988.

BD Pharmingen™ Purified Mouse Anti-Human CD112 - Purified - Clone R2.525 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: R2-525

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-PVRL2 antibody (ABIN2688890)

Lopez, Aoubala, Jordier, Isnardon, Gomez, Dubreuil: "The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule." in: Blood, Vol. 92, Issue 12, pp. 4602-11, (1999) (PubMed).

Eberlé, Dubreuil, Mattei, Devilard, Lopez: "The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene." in: Gene, Vol. 159, Issue 2, pp. 267-72, (1995) (PubMed).

Target Details for PVRL2

Target: PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))

Alternative Name: CD112 (PVRL2 Products)

Synonyms: prr2 antibody, AI325026 antibody, AI987993 antibody, Cd112 antibody, MPH antibody, Pvr antibody, Pvs antibody, nectin-2 antibody, CD112 antibody, HVEB antibody, PRR2 antibody, PVRR2 antibody, nectin cell adhesion molecule 2 antibody, Nectin2 antibody, NECTIN2 antibody

Background: Synonyms: PRR2

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization