CD79b Molecule, Immunoglobulin-Associated beta (CD79B) antibody

Details for Product No. ABIN2689397, Supplier: Log in to see
Antigen
  • B29
  • Ig-beta
  • Igb
  • Igbeta
  • AGM6
  • IGB
  • CD79B antigen
  • CD79b molecule
  • Cd79b
  • CD79B
Reactivity
Human
215
151
27
10
10
2
2
Host
Mouse
119
87
60
32
30
6
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
48
41
25
17
5
4
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
Application
Flow Cytometry (FACS)
222
198
102
92
51
47
17
13
8
5
4
4
4
2
2
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Brand BD Pharmingen™
Clone 3A2
Isotype IgG1, kappa
Characteristics Immunoglobulin (Ig) antigen receptors are composed of a non-covalently-associated complex of Ig and two other proteins, Igα and Igβ, clustered as CD79a and CD79b, respectively. CD79b is a membrane glycoprotein of 229 residues, with a predicted relative molecular mass of 36-40 kDa. Its expression is restricted to B lineage cells, has been reported to associate with surface IgM receptor, and may be involved in signal transduction. Antibody 3A2-2E7 (also known as SN8) was generated by immunization of cell membrane preparations from B-prolymphocytic leukemia cells. It has similar reactivity characteristics as clone CB3-1 (another CD79b available from BD Biosciences Pharmingen, Cat. No. 555678). Antibodies CD3-1 and 3A2-2E7 reacts with an epitope that is enhanced on certain B-cell leukemias such as prolymphocytic leukemia and lymphoma, but not on chronic lymphocytic leukemia. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of human CD79b expression on peripheral blood lymphocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.

BD Pharmingen™ Purified Mouse Anti-Human CD79b - Purified - Clone 3A2-2E7 (also known as SN8) - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Antigen
Alternative Name CD79b (CD79B Antibody Abstract)
Background Synonyms: Igβ/SN8/3A2-2E7-1F5
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.
Product cited in: Cragg, Chan, Fox, Tutt, Smith, Oscier, Hamblin, Glennie: "The alternative transcript of CD79b is overexpressed in B-CLL and inhibits signaling for apoptosis." in: Blood, Vol. 100, Issue 9, pp. 3068-76, 2002 (PubMed).

Van Kooten, Galibert, Seon, Garrone, Liu, Banchereau: "Cross-linking of antigen receptor via Ig-beta (B29, CD79b) can induce both positive and negative signals in CD40-activated human B cells." in: Clinical and experimental immunology, Vol. 110, Issue 3, pp. 509-15, 1998 (PubMed).

Moreau, Matutes, AHern, Morilla, Morilla, Owusu-Ankomah, Seon, Catovsky: "Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b)." in: American journal of clinical pathology, Vol. 108, Issue 4, pp. 378-82, 1997 (PubMed).

Zomas, Matutes, Morilla, Owusu-Ankomah, Seon, Catovsky: "Expression of the immunoglobulin-associated protein B29 in B cell disorders with the monoclonal antibody SN8 (CD79b)." in: Leukemia, Vol. 10, Issue 12, pp. 1966-70, 1997 (PubMed).

Astsaturov, Matutes, Morilla, Seon, Mason, Farahat, Catovsky: "Differential expression of B29 (CD79b) and mb-1 (CD79a) proteins in acute lymphoblastic leukaemia." in: Leukemia, Vol. 10, Issue 5, pp. 769-73, 1996 (PubMed).

Okazaki, Luo, Han, Yoshida, Seon: "Three new monoclonal antibodies that define a unique antigen associated with prolymphocytic leukemia/non-Hodgkin's lymphoma and are effectively internalized after binding to the cell surface antigen." in: Blood, Vol. 81, Issue 1, pp. 84-94, 1993 (PubMed).