Integrin beta 7 antibody

Catalog No. ABIN2689794

Product Details anti-Integrin beta 7 Antibody

Target: Integrin beta 7 (ITGB7)

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This Integrin beta 7 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Brand: BD Pharmingen™

Characteristics: FIB504 reacts with mouse integrin β7 subunit (130 kD) but also cross reacts with human integrin β7. Integrin β7 associates with α4 (CD49d) expressed on subsets of lymphocytes and thymus. It also associates with αIEL (CD103) expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Integrin β7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response. Profile of peripheral blood lymphocytes analyzed on a FACScan

BD Pharmingen™ Purified Rat Anti-Human Integrin β7 - Purified - Clone FIB504 - Isotype Rat IgG2a, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: FIB504

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-Integrin beta 7 antibody (ABIN2689794)

Butcher, Picker: "Lymphocyte homing and homeostasis." in: Science (New York, N.Y.), Vol. 272, Issue 5258, pp. 60-6, (1996) (PubMed).

Teague, Lazarovits, McIntyre: "Integrin alpha 4 beta 7 co-stimulation of human peripheral blood T cell proliferation." in: Cell adhesion and communication, Vol. 2, Issue 6, pp. 539-47, (1995) (PubMed).

Erle, Briskin, Butcher, Garcia-Pardo, Lazarovits, Tidswell: "Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 153, Issue 2, pp. 517-28, (1994) (PubMed).

Berlin, Berg, Briskin, Andrew, Kilshaw, Holzmann, Weissman, Hamann, Butcher: "Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1." in: Cell, Vol. 74, Issue 1, pp. 185-95, (1993) (PubMed).

Target Details for Integrin beta 7

Target: Integrin beta 7 (ITGB7)

Alternative Name: Integrin Beta7 (ITGB7 Products)

Synonyms: Ly69 antibody, integrin beta 7 antibody, integrin subunit beta 7 antibody, integrin, beta 7 antibody, Itgb7 antibody, ITGB7 antibody

Pathways: Integrin Complex