Oct-2 antibody

Catalog No. ABIN271754

Product Details anti-Oct-2 Antibody

Target: Oct-2 (POU2F2) (POU domain, class 2, transcription factor 2 (POU2F2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Oct-2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of OCT2/OTF2 (H3) protein. (region surrounding His3)

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Purity: > 95 % pure by SDS-PAGE

Application Details

Application Notes: ELISA: 1: 5000approx. 1: 10000. WB: 1: 500approx. 1: 1000. IF: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: DO NOT FREEZE!

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for Oct-2

Target: Oct-2 (POU2F2) (POU domain, class 2, transcription factor 2 (POU2F2))

Alternative Name: POU2F2 / OCT2 (POU2F2 Products)

Synonyms: OCT2 antibody, OTF2 antibody, Oct-2 antibody, Pou2f2 antibody, Oct2a antibody, Oct2b antibody, Otf-2 antibody, Otf2 antibody, 2-Oct antibody, Oct2 antibody, POU class 2 homeobox 2 antibody, POU domain, class 2, transcription factor 2 antibody, solute carrier family 22 (organic cation transporter), member 2 antibody, POU2F2 antibody, Pou2f2 antibody, SLC22A2 antibody

Background: Organic cation transporters (OCT) are expressed in the plasma membrane of epithelial cells from a wide range of tissues, where they function in the elimination of ndogenous amines, cationic drugs and other xenobiotics. The structure of OCTs consists of a 12-transmembrane-domain structure and a large extracellular hydrophilic loop. In humans, OCT1 is primarily expressed in the liver while OCT2 is expressed in the kidney. OCT3 is expressed in the placenta, skeletal muscle, prostate, aorta and liver. OCT3, also known as extraneuronal monoamine transporter, is widely expressed in different regions of the brain including the hippocampus, cerebellum and cerebral cortex. OCT3 mediates the uptake of several neuroactive agents, including dopamine, and may play an important role in the disposition of neurotransmitters and cationic neurotoxins in the brain. The genes encoding human OCT1-3 map to a conserved cluster at chromosome 6q26-q27.Synonyms: Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, OTF2, Oct-2, Octamer-binding protein 2, Octamer-binding transcription factor 2, Otf-2, POU domain class 2 transcription factor 2

Molecular Weight: approx. 52 kDa

Gene ID: 5452

NCBI Accession: NP_001193954

UniProt: P09086