GTF2IRD1 antibody

Catalog No. ABIN272259

Product Details anti-GTF2IRD1 Antibody

Target: GTF2IRD1 (General Transcription Factor II I Repeat Domain-Containing 1 (GTF2IRD1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GTF2IRD1 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects endogenous levels of WBSCR11 protein. (region surrounding Lys94)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen

Application Details

Application Notes: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GTF2IRD1

Target: GTF2IRD1 (General Transcription Factor II I Repeat Domain-Containing 1 (GTF2IRD1))

Alternative Name: GTF2IRD1 / CREAM1 (GTF2IRD1 Products)

Synonyms: Gtf3 antibody, 1700012P16Rik antibody, BEN antibody, Cream1 antibody, ESTM9 antibody, GTF3 antibody, Gtf2il antibody, MusTRD1 antibody, Tg(Alb1-Myc)166.8Sst antibody, WBSCR11 antibody, X83320 antibody, GTF2IRD1 antibody, CREAM1 antibody, MUSTRD1 antibody, RBAP2 antibody, WBS antibody, WBSCR12 antibody, hMusTRD1alpha1 antibody, XBEN antibody, XWBSCR11 antibody, cream1 antibody, gtf3 antibody, mustrd1 antibody, rbap2 antibody, wbs antibody, wbscr11 antibody, wbscr12 antibody, GTF2I repeat domain containing 1 antibody, general transcription factor II I repeat domain-containing 1 antibody, general transcription factor II-I repeat domain-containing protein 1 antibody, GTF2I repeat domain containing 1 S homeolog antibody, GTF2IRD1 antibody, Gtf2ird1 antibody, gtf2ird1 antibody, LOC100461122 antibody, gtf2ird1.S antibody

Background: Williams-Beuren syndrome (WBS) is a developmental disorder caused by the hemizygous microdeletion on chromosome 7q11.23. WBS is an autosomal dominant genetic condition that is characterized by physical, cognitive and behavioral traits. The physical traits associated with WBS include facial dysmorphology, vascular stenoses, growth deficiencies, dental anomalies and neurologic and musculoskeletal abnormalities. Mild retardation, a weakness in visual-spatial skills, anxiety and a short attention span are typical cognitive and behavioral traits of WBS patients. The WBSCR11 gene is located within the WBS deletion and may contribute to the developmental symptoms found in WBS because of a loss of the encoded transcription factor. WBSCR11 is also designated GRF2IRD1, GTF3, Cream1 and MusTRD1 in human and BEN in mouse, due to slight differences in gene structure. WBSCR11 is expressed in all adult tissues as several variants and has discrete spatial and temporal expression during embryogenesis.Synonyms: GTF2I repeat domain-containing protein 1, GTF2I repeat domain-containing protein 1, GTF3, General transcription factor II-I repeat domain-containing protein 1, General transcription factor III, MUSTRD1, MusTRD1/BEN, Muscle TFII-I repeat domain-containing protein 1, RBAP2, Slow-muscle-fiber enhancer-binding protein, USE B1-binding protein, WBSCR11, WBSCR12, Williams-Beuren syndrome chromosomal region 11 protein

Molecular Weight: approx. 106 kDa

Gene ID: 9569

NCBI Accession: NP_001186136

UniProt: Q9UHL9