Cadherin 13 antibody

Catalog No. ABIN272293

Product Details anti-Cadherin 13 Antibody

Target: Cadherin 13 (CDH13)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cadherin 13 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificity: This antibody detects endogenous levels of T-Cadherin protein. (region surrounding Met352)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen

Application Details

Application Notes: ELISA: 1/20000approx. 1/40000. Western Blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/200. Immunofluorescence: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Cadherin 13

Target: Cadherin 13 (CDH13)

Alternative Name: Cadherin-13 (CDH13 Products)

Synonyms: CDH13 antibody, CDHH antibody, P105 antibody, 4932416G01Rik antibody, Cdht antibody, T-cadherin antibody, Tcad antibody, cadherin 13 antibody, CDH13 antibody, Cdh13 antibody

Background: The cadherins are a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including β-catenin, to regulate cadherin function. T-cadherin (for truncated-cadherin, also designated heartcadherin or cadherin-13) expression levels have been shown to be reduced in human breast cancers and carcinoma cells lines. Evidence suggests that decreased levels of T-cadherin indicate a progression in breast malignancies.Synonyms: CDH13, CDHH, Cadherin H, Cadherin T, H-Cadherin, Heart cadherin, P105, T-Cadherin, Truncated cadherin

Molecular Weight: approx. 78 kDa

Gene ID: 1012

NCBI Accession: NP_001248

UniProt: P55290

Pathways: EGFR Signaling Pathway, Cell-Cell Junction Organization