RASSF1 antibody

Catalog No. ABIN2730552

The Mouse Monoclonal anti-RASSF1 antibody is suitable to detect RASSF1 in samples from Human. It has been validated for WB, IF, IHC and FACS.

Quick Overview for RASSF1 antibody (ABIN2730552)

Target: RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RASSF1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 2B11

Product Details anti-RASSF1 Antibody

Characteristics: Homo sapiens Ras association (RalGDS/AF-6) domain family member 1 (RASSF1), transcript variant A

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human RASSF1 (NP_009113) produced in E.coli.

Isotype: IgG1

Application Details

Application Notes: WB 1:2000, IHC 1:150, IF 1:100, FLOW 1:100

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for RASSF1

Target: RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))

Alternative Name: RASSF1

Background: This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Molecular Weight: 38.6 kDa

Gene ID: 11186

NCBI Accession: NM_007182

HGNC: 28844