CD161 antibody (PE)
-
- Target See all CD161 (KLRB1) Antibodies
- CD161 (KLRB1) (Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1))
-
Reactivity
- Rat
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- This CD161 antibody is conjugated to PE
-
Application
- Flow Cytometry (FACS)
- Specificity
- The mouse monoclonal antibody 10/78 recognizes CD161, an approximately 30 kDa type II transmembrane C-type lectin receptor, expressed on the plasma membrane of NK cells, dendritic cells, activated monocytes and a subset of T cells as a disulphide-linked homodimer. A common extracellular epitope on rat CD161a and b isoforms is detected.
- Cross-Reactivity (Details)
- Rat
- Purification
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Immunogen
- Splenic cells purified from the LEW rat
- Clone
- 10-78
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product KLRB1 Primary Antibody
-
-
- Application Notes
- Flow cytometry: Recommended dilution: 1-5 μg/mL.
- Comment
-
The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
- Restrictions
- For Research Use only
-
- Concentration
- 0.5 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
-
-
The immunization site of cytokine-secreting tumor cell vaccines influences the trafficking of tumor-specific T lymphocytes and antitumor efficacy against regional tumors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 10, pp. 6025-32, (2004) (PubMed).
: "Phenotypic characterization of regulatory CD4+CD25+ T cells in rats." in: International immunology, Vol. 16, Issue 2, pp. 365-75, (2004) (PubMed).
: "CD8 alpha beta T cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 2, pp. 1099-105, (2003) (PubMed).
: "Evaluation of the hepatic NK cell response during the early phase of Fasciola hepatica infection in rats." in: Veterinary research, Vol. 33, Issue 3, pp. 327-32, (2002) (PubMed).
: "Central nervous system microglial cell activation and proliferation follows direct interaction with tissue-infiltrating T cell blasts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 11, pp. 5320-30, (1998) (PubMed).
: "Negative regulation of rat natural killer cell activity by major histocompatibility complex class I recognition." in: European journal of immunology, Vol. 26, Issue 11, pp. 2582-6, (1997) (PubMed).
: "
-
The immunization site of cytokine-secreting tumor cell vaccines influences the trafficking of tumor-specific T lymphocytes and antitumor efficacy against regional tumors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 10, pp. 6025-32, (2004) (PubMed).
-
- Target
- CD161 (KLRB1) (Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1))
- Alternative Name
- CD161 (KLRB1 Products)
- Synonyms
- NKR-P1 antibody, KLRB1 antibody, 4930431A04Rik antibody, Gm4696 antibody, Klrb1g antibody, Klrb6 antibody, Ly-55 antibody, Ly55 antibody, NKR-P1G antibody, Nkrp-1e antibody, Nkrp1g antibody, CD161 antibody, CLEC5B antibody, NKR antibody, NKR-P1A antibody, NKRP1A antibody, hNKR-P1A antibody, Klrb1d antibody, Klrb1f antibody, Nkr-p1e antibody, killer cell lectin like receptor B1 antibody, killer cell lectin-like receptor subfamily B member 1 antibody, killer cell lectin-like receptor subfamily B, member 1 antibody, KLRB1 antibody, Klrb1 antibody
- Background
- Killer cell lectin-like receptor subfamily B, memb,CD161, also known as Nkrp1 (natural killer receptor protein 1) or Klrb1 (killer cell lectin-like receptor subfamily b member 1), is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on rat NK cells, subset of T cells, dendritic cells, and activated monocytes. Although human CD161 is expressed as one isoform, the rat CD161 has three isoforms, referred to as CD161a, b, and c. These proteins contain C-terminal C-type lectin extracellular domain, a transmembrane domain, and N-terminal intracellular domain, which contains ITIM motif, such as CD161b, and displays inhibitory function, or does not contain ITIM motif, thus also not the inhibitory function, such as CD161a.,NKRP1A, Klrb
- Gene ID
- 689817
- UniProt
- Q0ZUP0
-