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TNFRSF12A antibody
TNFRSF12A
Reactivity: Human, Mouse
WB, FACS, IHC (fro)
Host: Mouse
Monoclonal
ITEM-4
unconjugated
Product Details anti-TNFRSF12A Antibody
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Target
See all TNFRSF12A Antibodies
TNFRSF12A
(Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))
Reactivity
All reactivities for TNFRSF12A antibodies
Human, Mouse
Host
All hosts for TNFRSF12A antibodies
Mouse
Clonality
All clonalities for TNFRSF12A antibodies
Monoclonal
Conjugate
All conjugates for TNFRSF12A antibodies
This TNFRSF12A antibody is un-conjugated
Application
All applications for TNFRSF12A antibodies
Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
Specificity
The mouse monoclonal antibody ITEM-4 recognizes an extracellular epitope of CD266 / TWEAK R, a TNFR superfamily receptor for CD255 / TWEAK, a TNF-like weak inducer of apoptosis.
Cross-Reactivity (Details)
Human, Mouse
Purification
Purified by protein-A affinity chromatography.
Purity
> 95 % (by SDS-PAGE)
Immunogen
human CD266-transfected P815 cells
Clone
ITEM-4
Isotype
IgG2b
Top Product
Discover our top product TNFRSF12A Primary Antibody
Alternatives
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anti-Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) (AA 104-118) antibody
TNFRSF12A
Reactivity: Human, Mouse, Rat, Rabbit, Dog, Horse, Cow, Monkey, Bat, Hamster
WB
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
Flow cytometry: Recommended dilution: 1-4 μg/mL
Restrictions
For Research Use only
Handling
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Concentration
1 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
Store at 2-8°C. Do not freeze.
References for anti-TNFRSF12A antibody (ABIN2749054)
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Yoriki, Akashi, Sho, Nomi, Yamato, Hotta, Takayama, Matsumoto, Wakatsuki, Migita, Yagita, Nakajima : "Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer. " in: Experimental and therapeutic medicine , Vol. 2 , Issue 1 , pp. 103-108 , (2012 ) (PubMed ).
Roos, Wicovsky, Müller, Salzmann, Rosenthal, Kalthoff, Trauzold, Seher, Henkler, Kneitz, Wajant : "Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway. " in: Journal of immunology (Baltimore, Md. : 1950) , Vol. 185 , Issue 3 , pp. 1593-605 , (2010 ) (PubMed ).
Nakayama, Ishidoh, Kojima, Harada, Kominami, Okumura, Yagita : "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. " in: Journal of immunology (Baltimore, Md. : 1950) , Vol. 170 , Issue 1 , pp. 341-8 , (2002 ) (PubMed ).
Target Details for TNFRSF12A
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Target
TNFRSF12A
(Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))
Alternative Name
CD266 / TWEAK R (TNFRSF12A Products )
Synonyms
CD266 antibody, FN14 antibody, TWEAKR antibody, AI255180 antibody, C87282 antibody, Fn14 antibody, HPIP antibody, TWEAK-R antibody, TweakR antibody, TNF receptor superfamily member 12A antibody, tumor necrosis factor receptor superfamily, member 12a antibody, TNFRSF12A antibody, Tnfrsf12a antibody
Background
TNF receptor superfamily member 12A,CD266 / TWEAK R (TNFRSF12A), also known as FN14 (fibroblast growth factor-inducible 14) is a receptor for CD255 / TWEAK, the TNF-like weak inducer of apoptosis. CD266 is expressed on endothelial cells, as well as on some cancer tissues, and plays a role in CD255-induced endothelial cell migration, proliferation, and angiogenesis. The CD255-CD266 interaction, or antibody-mediated triggering of CD266 is also able to induce apoptosis and necrosis in CD266-positive cells (including tumor cells), which might have therapeutic potential.,TWEAKR, FN14, TNFRSF12A
Gene ID
51330
UniProt
Q9NP84
Pathways
Apoptosis , Regulation of Cell Size
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