hCoV-OC43 Spike antibody (AA 15-344) (HRP)

Catalog No. ABIN2754655

Product Details anti-hCoV-OC43 Spike Antibody (HRP)

Target: hCoV-OC43 Spike (HCoV-OC43 S) (Coronavirus OC43 Spike Protein (HCoV-OC43 S))

Binding Specificity: AA 15-344

Reactivity: Human Coronavirus OC43 (HCoV-OC43)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This hCoV-OC43 Spike antibody is conjugated to HRP

Application: ELISA

Purification: Caprylic Acid Ammonium Sulfate Precipitation

Immunogen: Recombinant Human coronavirus OC43 Spike glycoprotein protein(15-344aa)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C/-80 °C

Target Details for hCoV-OC43 Spike

Target: hCoV-OC43 Spike (HCoV-OC43 S) (Coronavirus OC43 Spike Protein (HCoV-OC43 S))

Alternative Name: OC43 Spike Glycoprotein (HCoV-OC43 S Products)

Target Type: Viral Protein

Background: S1 attaches the virion to the cell membrane by interacting with sialic acid-containing cell receptors, initiating the infection. S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.

UniProt: P36334