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DTX2 antibody (C-Term)

DTX2 Reactivity: Human, Mouse, Rat, Dog, Cow, Zebrafish (Danio rerio), Goat, Guinea Pig, Horse, Rabbit WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2774772
  • Target See all DTX2 Antibodies
    DTX2 (Deltex Homolog 2 (DTX2))
    Binding Specificity
    • 15
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 27
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog, Cow, Zebrafish (Danio rerio), Goat, Guinea Pig, Horse, Rabbit
    Host
    • 24
    • 2
    • 1
    Rabbit
    Clonality
    • 27
    Polyclonal
    Conjugate
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DTX2 antibody is un-conjugated
    Application
    • 25
    • 13
    • 13
    • 8
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB)
    Sequence
    EDCGTILIVY SIPHGIQGPE HPNPGKPFTA RGFPRQCYLP DNAQGRKVLE
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
    Characteristics
    This is a rabbit polyclonal antibody against DTX2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human DTX2
    Top Product
    Discover our top product DTX2 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 575 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    DTX2 (Deltex Homolog 2 (DTX2))
    Alternative Name
    DTX2 (DTX2 Products)
    Synonyms
    RNF58 antibody, 2610524D08Rik antibody, AA408415 antibody, AU022494 antibody, Deltex2 antibody, dtx2 antibody, deltex E3 ubiquitin ligase 2 antibody, probable E3 ubiquitin-protein ligase DTX2 antibody, deltex 2, E3 ubiquitin ligase antibody, deltex 2, E3 ubiquitin ligase S homeolog antibody, DTX2 antibody, Dtx2 antibody, LOC735784 antibody, LOC747633 antibody, dtx2 antibody, dtx2.S antibody
    Background
    DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. DTX2 probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context and mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. It also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
    Alias Symbols: KIAA1528, MGC71098, RNF58
    Protein Interaction Partner: KRTAP26-1, RFX6, KLC3, GLYCTK, DTX2, RIMBP3, C1orf94, NCALD, PLEKHF2, TRIM54, EIF4ENIF1, ALKBH4, UBE2D4, HPCAL4, SPG21, SEC22A, SPAG8, STX12, NCS1, FAM168A, RBPMS, SEC23B, ABHD16A, VSNL1, SUMO1, UBE2D3, UBE2D1, UBC, TRIP6, QARS, HDC, GOLGA2, FHL2, ARNT2,
    Protein Size: 575
    Molecular Weight
    62 kDa
    Gene ID
    113878
    NCBI Accession
    NM_001102596, NP_001096066
    UniProt
    Q6XM87
    Pathways
    Notch Signaling
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