DTX2 antibody (C-Term)
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- Target See all DTX2 Antibodies
- DTX2 (Deltex Homolog 2 (DTX2))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Rat, Dog, Cow, Zebrafish (Danio rerio), Goat, Guinea Pig, Horse, Rabbit
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This DTX2 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- EDCGTILIVY SIPHGIQGPE HPNPGKPFTA RGFPRQCYLP DNAQGRKVLE
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
- Characteristics
- This is a rabbit polyclonal antibody against DTX2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human DTX2
- Top Product
- Discover our top product DTX2 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 575 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- DTX2 (Deltex Homolog 2 (DTX2))
- Alternative Name
- DTX2 (DTX2 Products)
- Synonyms
- RNF58 antibody, 2610524D08Rik antibody, AA408415 antibody, AU022494 antibody, Deltex2 antibody, dtx2 antibody, deltex E3 ubiquitin ligase 2 antibody, probable E3 ubiquitin-protein ligase DTX2 antibody, deltex 2, E3 ubiquitin ligase antibody, deltex 2, E3 ubiquitin ligase S homeolog antibody, DTX2 antibody, Dtx2 antibody, LOC735784 antibody, LOC747633 antibody, dtx2 antibody, dtx2.S antibody
- Background
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DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. DTX2 probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context and mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. It also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Alias Symbols: KIAA1528, MGC71098, RNF58
Protein Interaction Partner: KRTAP26-1, RFX6, KLC3, GLYCTK, DTX2, RIMBP3, C1orf94, NCALD, PLEKHF2, TRIM54, EIF4ENIF1, ALKBH4, UBE2D4, HPCAL4, SPG21, SEC22A, SPAG8, STX12, NCS1, FAM168A, RBPMS, SEC23B, ABHD16A, VSNL1, SUMO1, UBE2D3, UBE2D1, UBC, TRIP6, QARS, HDC, GOLGA2, FHL2, ARNT2,
Protein Size: 575 - Molecular Weight
- 62 kDa
- Gene ID
- 113878
- NCBI Accession
- NM_001102596, NP_001096066
- UniProt
- Q6XM87
- Pathways
- Notch Signaling
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