GRIK1 antibody (Middle Region)

Catalog No. ABIN2776118

Product Details anti-GRIK1 Antibody

Target: GRIK1 (Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Rabbit, Horse, Cow, Dog, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIK1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IQTRWKHPSV DNRDLFYINL YPDYAAISRA VLDLVLYYNW KTVTVVYEDS

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against Grik1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of mouse GRIK1

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GRIK1

Target: GRIK1 (Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1))

Alternative Name: Grik1 (GRIK1 Products)

Background: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG, Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.
Alias Symbols: GluK1, GluK5, Glur5, Glur-5, D16Ium24, D16Ium24e, Glurbeta1, A830007B11Rik
Protein Size: 589

Molecular Weight: 64 kDa

Gene ID: 14805

NCBI Accession: XM_006522921, XP_006522984

UniProt: Q8C825

Pathways: Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity