TRPV4 antibody (Middle Region)
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- Target See all TRPV4 Antibodies
- TRPV4 (Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Mouse, Rat, Cow, Pig, Dog, Rabbit, Guinea Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TRPV4 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- RVDEVNWSHW NQNLGIINED PGKNETYQYY GFSHTVGRLR RDRWSSVVPR
- Predicted Reactivity
- Cow: 93%, Dog: 86%, Guinea Pig: 86%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 100%, Rat: 93%
- Characteristics
- This is a rabbit polyclonal antibody against TRPV4. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human TRPV4
- Top Product
- Discover our top product TRPV4 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 811 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- TRPV4 (Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4))
- Alternative Name
- TRPV4 (TRPV4 Products)
- Synonyms
- wu:fp52e02 antibody, CMT2C antibody, HMSN2C antibody, OTRPC4 antibody, SMAL antibody, SPSMA antibody, SSQTL1 antibody, TRP12 antibody, VRL2 antibody, VROAC antibody, 0610033B08Rik antibody, Trp12 antibody, VR-OAC antibody, VRL-2 antibody, Otrpc4 antibody, Vroac antibody, transient receptor potential cation channel, subfamily V, member 4 antibody, transient receptor potential cation channel subfamily V member 4 antibody, trpv4 antibody, TRPV4 antibody, Trpv4 antibody
- Background
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TRPV4 is a non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation of TRPV4 by exposure to hypotonicity within the physiological range exhibits an outward rectification. TRPV4 also activated by low pH , citrate and phorbol esters and increase of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism.Defects in TRPV4 are the cause of brachyolmia type 3 (BRAC3) This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: OTRPC4, TRP12, VR-OAC, VRL-2, VRL2, VROAC, CMT2C, SPSMA, HMSN2C, SSQTL1
Protein Interaction Partner: UBC, ARRB2, KRIT1, ITCH, PACSIN3, PACSIN1, TRPV4, PACSIN2, MAP7, SRC, LYN, YES1, LCK, HCK, FYN, CALM1, OS9, PACS1,
Protein Size: 811 - Molecular Weight
- 91 kDa
- Gene ID
- 59341
- NCBI Accession
- NM_147204, NP_671737
- Pathways
- Hormone Transport, Cell-Cell Junction Organization
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