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BAD antibody (Middle Region)

This Rabbit Polyclonal antibody specifically detects BAD in WB. It exhibits reactivity toward Human, Mouse, Rat, Rabbit, Cow, Guinea Pig and Horse and has been mentioned in 2+ publications.
Catalog No. ABIN2779311

Quick Overview for BAD antibody (Middle Region) (ABIN2779311)

Target

See all BAD Antibodies
BAD (BCL2-Associated Agonist of Cell Death (BAD))

Reactivity

  • 364
  • 214
  • 138
  • 18
  • 10
  • 6
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Mouse, Rat, Rabbit, Cow, Guinea Pig, Horse

Host

  • 431
  • 14
  • 1
Rabbit

Clonality

  • 415
  • 31
Polyclonal

Conjugate

  • 181
  • 38
  • 35
  • 35
  • 32
  • 29
  • 6
  • 6
  • 6
  • 6
  • 6
  • 6
  • 6
  • 6
  • 6
  • 6
  • 6
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
This BAD antibody is un-conjugated

Application

  • 256
  • 232
  • 163
  • 93
  • 81
  • 80
  • 54
  • 51
  • 23
  • 21
  • 14
  • 12
  • 10
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)
  • Binding Specificity

    • 35
    • 33
    • 27
    • 25
    • 23
    • 23
    • 22
    • 22
    • 15
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region

    Sequence

    GAVEIRSRHS SYPAGTEDDE GMGEEPSPFR GRSRSAPPNL WAAQRYGREL

    Predicted Reactivity

    Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

    Characteristics

    This is a rabbit polyclonal antibody against BAD. It was validated on Western Blot.

    Purification

    Affinity Purified
  • Application Notes

    Optimal working dilutions should be determined experimentally by the investigator.

    Comment

    Antigen size: 168 AA

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handling Advice

    Avoid repeated freeze-thaw cycles.

    Storage

    -20 °C

    Storage Comment

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Mishra, Thakur, Somal, Parmar, Yadav, Bharati, Bharti, Paul, Verma, Chouhan, Sharma, Singh, González, DOcchio, Sarkar et al.: "Expression and localization of angiopoietin family in buffalo ovarian follicles during different stages of development and modulatory role of angiopoietins on steroidogenesis and survival of cultured ..." in: Theriogenology, Vol. 86, Issue 7, pp. 1818-33, (2016) (PubMed).

    Mishra, Parmar, Yadav, Reshma, Bharati, Bharti, Paul, Chouhan, Taru Sharma, Singh, Sarkar et al.: "Expression and localization of angiopoietin family in corpus luteum during different stages of oestrous cycle and modulatory role of angiopoietins on steroidogenesis, angiogenesis and survivability ..." in: Reproduction in domestic animals = Zuchthygiene, Vol. 51, Issue 6, pp. 855-869, (2016) (PubMed).

  • Target

    BAD (BCL2-Associated Agonist of Cell Death (BAD))

    Alternative Name

    BAD

    Background

    The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
    Alias Symbols: BBC2, BCL2L8
    Protein Interaction Partner: BCL2L1, BCL2, AKT1, PAK1, BMH1, YWHAB, SFN, YWHAZ, RAF1, PRKACA, BRAF, ARAF, CREB3L3, STEAP3, YWHAQ, KEAP1, YWHAH, YWHAE, PRDX2, CDKN1A, VCP, SNCA, PPP1CA, BAX, SUMO2, YWHAG, PIM3, MCL1, RPS6KA5, PAK7, BCL2L10, WASF1, HRK, MAP2K5, BCL2L2, RPS6KA2, RPS6KA1
    Protein Size: 168

    Molecular Weight

    18 kDa

    Gene ID

    572

    NCBI Accession

    NM_004322, NP_004313

    UniProt

    Q92934

    Pathways

    MAPK Signaling, PI3K-Akt Signaling, RTK Signaling, Apoptosis, Fc-epsilon Receptor Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Hepatitis C, CXCR4-mediated Signaling Events
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