PIAS1 antibody (Middle Region)

Catalog No. ABIN2780998

This Rabbit Polyclonal antibody specifically detects PIAS1 in WB. It exhibits reactivity toward Human, Horse, Cow and Dog.

Quick Overview for PIAS1 antibody (Middle Region) (ABIN2780998)

Target: PIAS1 (Protein Inhibitor of Activated STAT, 1 (PIAS1))

Reactivity: Human, Horse, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIAS1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PIAS1 Antibody

Binding Specificity: Middle Region

Sequence: LPTTNGSSSG SNSSLVSSNS LRESHSHTVT NRSSTDTASI FGIIPDIISL

Predicted Reactivity: Cow: 79%, Dog: 93%, Horse: 79%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against PIAS1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PIAS1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 651 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PIAS1

Target: PIAS1 (Protein Inhibitor of Activated STAT, 1 (PIAS1))

Alternative Name: PIAS1

Background: PIAS1 is a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene act
Alias Symbols: DDXBP1, GBP, GU/RH-II, MGC141878, MGC141879, ZMIZ3
Protein Interaction Partner: STAT1, TRIM63, TRIM55, CEP250, PRDM1, SUMO1, L3MBTL2, CBS, SHFM1, SUMO2, SUMO3, SOX2, CHUK, SPOP, YWHAZ, UBC, SKIL, SGTA, ATXN1, SMAD7, SMAD4, SMAD1, HTT, PRPF40A, PPP1CC, BARD1, PAXIP1, NR1H2, PPARGC1A, NR1H3, PPARGC1B, RAD54L2, ZMYND11, UBD, PLAG1, MYB,
Protein Size: 651

Molecular Weight: 72 kDa

Gene ID: 8554

NCBI Accession: NM_016166, NP_057250

UniProt: O75925

Pathways: JAK-STAT Signaling, Interferon-gamma Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Hepatitis C