ACVRL1 antibody (N-Term)

Catalog No. ABIN2781759

This Rabbit Polyclonal antibody specifically detects ACVRL1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Pig and Horse.

Quick Overview for ACVRL1 antibody (N-Term) (ABIN2781759)

Target: ACVRL1 (Activin A Receptor Type II-Like 1 (ACVRL1))

Reactivity: Human, Mouse, Rat, Dog, Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACVRL1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ACVRL1 Antibody

Binding Specificity: N-Term

Sequence: SPHCKGPTCR GAWCTVVLVR EEGRHPQEHR GCGNLHRELC RGRPTEFVNH

Predicted Reactivity: Dog: 100%, Horse: 93%, Human: 100%, Mouse: 92%, Pig: 93%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against ACVRL1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ACVRL1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 503 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ACVRL1

Target: ACVRL1 (Activin A Receptor Type II-Like 1 (ACVRL1))

Alternative Name: ACVRL1

Background: ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. ACVRL1, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
Alias Symbols: ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I
Protein Interaction Partner: TGFBR1, TGFB1, INHBA, SMAD1, PEG10, NR1H2, FKBP1A, CSNK2B, ENG, BAMBI, HSP90AA1, IGSF1, TSC22D1, SNX6, TGFBRAP1, XIAP, TGFB3, TGFBR2, ACVR2A,
Protein Size: 503

Molecular Weight: 55 kDa

Gene ID: 94

NCBI Accession: NM_000020, NP_000011

UniProt: P37023