JAG2 antibody (N-Term)

Catalog No. ABIN2782165

This Rabbit Polyclonal antibody specifically detects JAG2 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat and Pig.It has been mentioned in 1 publication

Quick Overview for JAG2 antibody (N-Term) (ABIN2782165)

Target: JAG2 (Jagged 2 (JAG2))

Reactivity: Human, Mouse, Rat, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JAG2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-JAG2 Antibody

Binding Specificity: N-Term

Purpose: JAG2 Antibody - N-terminal region

Sequence: RAQGRGRLPR RLLLLLALWV QAARPMGYFE LQLSALRNVN GELLSGACCD

Predicted Reactivity: Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against JAG2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human JAG2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45254-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-JAG2 antibody (ABIN2782165)

Passos Gregorio, Gattaz, Tavares, Kieling, Timm, Wang, Berg Rasmussen, Werge, Dias-Neto: "Analysis of coding-polymorphisms in NOTCH-related genes reveals NUMBL poly-glutamine repeat to be associated with schizophrenia in Brazilian and Danish subjects." in: Schizophrenia research, Vol. 88, Issue 1-3, pp. 275-82, (2006) (PubMed).

Target Details for JAG2

Target: JAG2 (Jagged 2 (JAG2))

Alternative Name: JAG2

Background:

Background Information: The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch protein family are transmembrane receptors that are critical for various cell fate decisions. JAG2 is one of several ligands that activate Notch and related receptors. The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: Jagged 2

Alternative Symbols: HJ2, SER2

Protein Name: Protein jagged-2

Molecular Weight: 130kDa

Gene ID: 3714

NCBI Accession: NP_002217

UniProt: Q9Y219

Pathways: Notch Signaling, Sensory Perception of Sound