MDH1 antibody (Middle Region)

Catalog No. ABIN311017

Product Details anti-MDH1 Antibody

Target: MDH1 (Malate Dehydrogenase 1, NAD (Soluble) (MDH1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Horse, Rabbit, Dog, Guinea Pig, Zebrafish (Danio rerio), Goat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MDH1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: NFSCLTRLDH NRAKAQIALK LGVTANDVKN VIIWGNHSST QYPDVNHAKV

Predicted Reactivity: Cow: 100%, Dog: 93%, Goat: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against MDH1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MDH1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 334 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-MDH1 antibody (ABIN311017)

Nussbaumer, Asara, Teplytska, Murphy, Logan, Turck, Filiou: "Selective Mitochondrial Targeting Exerts Anxiolytic Effects In Vivo." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 41, Issue 7, pp. 1751-8, (2016) (PubMed).

Povlsen, Løfgren, Dalgas, Birkler, Johannsen, Støttrup, Bøtker: "Protection against myocardial ischemia-reperfusion injury at onset of type 2 diabetes in Zucker diabetic fatty rats is associated with altered glucose oxidation." in: PLoS ONE, Vol. 8, Issue 5, pp. e64093, (2013) (PubMed).

Target Details for MDH1

Target: MDH1 (Malate Dehydrogenase 1, NAD (Soluble) (MDH1))

Alternative Name: MDH1 (MDH1 Products)

Synonyms: MDH-s antibody, MDHA antibody, MGC:1375 antibody, MOR2 antibody, ODS1 antibody, B230377B03Rik antibody, D17921 antibody, Mor-2 antibody, Mor2 antibody, MDL1 antibody, Mdhl antibody, MDH antibody, mdh-s antibody, mdha antibody, mor2 antibody, MDH-1 antibody, Mdh antibody, Mdh-1 antibody, Mdh2 antibody, MdhD antibody, cMdh antibody, sMdh antibody, malate dehydrogenase 1 antibody, malic enzyme 2 antibody, malate dehydrogenase 1, NAD (soluble) antibody, malate dehydrogenase 1 S homeolog antibody, malate dehydrogenase, cytoplasmic antibody, Malate dehydrogenase 1 antibody, MDH1 antibody, ME2 antibody, Mdh1 antibody, mdh1.S antibody, LOC100280767 antibody

Background: Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. MDH1 is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria.Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MDH-s, MDHA, MGC:1375, MOR2
Protein Interaction Partner: ISG15, UBC, NEDD8, PARK2, HSP90AB1, HSP90AA1, FUS, IQCB1, SDHA, PGM1, LDHA, ESD, Htt, PRDX5, PRDX6, SLC9A3R1, AKT1, TERF2IP, TERF1, TP53, EGFR, MPP3, MDH1, GPD1,
Protein Size: 334

Molecular Weight: 36 kDa

Gene ID: 4190

NCBI Accession: NM_005917, NP_005908

UniProt: P40925