Manic Fringe antibody (C-Term)
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- Target See all Manic Fringe (MFNG) Antibodies
- Manic Fringe (MFNG) (MFNG)
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Rat, Dog, Horse, Rabbit, Cow, Guinea Pig, Zebrafish (Danio rerio), Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Manic Fringe antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- QLLRTAQLPE QVTLSYGVFE GKLNVIKLQG PFSPEEDPSR FRSLHCLLYP
- Predicted Reactivity
- Cow: 92%, Dog: 100%, Guinea Pig: 85%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 83%
- Characteristics
- This is a rabbit polyclonal antibody against MFNG. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human MFNG
- Top Product
- Discover our top product MFNG Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 321 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Manic Fringe (MFNG) (MFNG)
- Alternative Name
- MFNG (MFNG Products)
- Synonyms
- AW546563 antibody, MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase antibody, MFNG antibody, Mfng antibody
- Background
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MFNG is one of the evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene is a member of the fringe gene family which also includes Radical and Lunatic fringe. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: -
Protein Interaction Partner: DLL1, JAG1, NOTCH2, NOTCH1,
Protein Size: 321 - Molecular Weight
- 36 kDa
- Gene ID
- 4242
- NCBI Accession
- NM_002405, NP_002396
- UniProt
- O00587
- Pathways
- Notch Signaling
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