ASZ1 antibody (Middle Region)

Catalog No. ABIN2784974

Product Details anti-ASZ1 Antibody

Target: ASZ1 (Ankyrin Repeat, SAM and Basic Leucine Zipper Domain Containing 1 (ASZ1))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Mouse, Guinea Pig, Horse, Rabbit, Cow, Dog, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ASZ1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GKMPSEIAKR NKHHEIFNLL SFTLNPLEGK LQQLTKEDTI CKILTTDSDR

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 93%

Characteristics: This is a rabbit polyclonal antibody against ASZ1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ASZ1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 475 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ASZ1

Target: ASZ1 (Ankyrin Repeat, SAM and Basic Leucine Zipper Domain Containing 1 (ASZ1))

Alternative Name: ASZ1 (ASZ1 Products)

Synonyms: Gasz antibody, GASZ antibody, gasz antibody, MGC56332 antibody, zgc:56332 antibody, ALP1 antibody, ANKL1 antibody, C7orf7 antibody, CT1.19 antibody, Orf3 antibody, 4933400N19Rik antibody, ORF3 antibody, ankyrin repeat, SAM and basic leucine zipper domain containing 1 antibody, Asz1 antibody, ASZ1 antibody, asz1 antibody

Background: ASZ1 plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity.ASZ1 acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process.ASZ1 is required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in regulation of retrotransposons.ASZ1 may act by mediating protein-protein interactions during germ cell maturation.
Alias Symbols: ALP1, ANKL1, C7orf7, GASZ, MGC26634, Orf3, CT1.19
Protein Interaction Partner: TSG101,
Protein Size: 475

Molecular Weight: 53 kDa

Gene ID: 136991

NCBI Accession: NM_130768, NP_570124

UniProt: Q8WWH4