ASPA antibody (Middle Region)

Catalog No. ABIN2786498

Product Details anti-ASPA Antibody

Target: ASPA (Aspartoacylase (ASPA))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ASPA antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IKTSLAPLPC YVYLIEHPSL KYATTRSIAK YPVGIEVGPQ PQGVLRADIL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against ASPA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ASPA

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 313 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ASPA

Target: ASPA (Aspartoacylase (ASPA))

Alternative Name: ASPA (ASPA Products)

Synonyms: asp antibody, acy2 antibody, ACY-2 antibody, ASP antibody, ACY2 antibody, Acy-2 antibody, Acy2 antibody, nur7 antibody, zgc:171507 antibody, aspartoacylase antibody, Aspartoacylase antibody, ASPA antibody, aspa antibody, Fbal_2465 antibody, Aspa antibody

Background: ASPA catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it acts as a scavenger of NAA from body fluids.This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene.
Alias Symbols: ACY2, ASP
Protein Interaction Partner: ACY3, ASPA,
Protein Size: 313

Molecular Weight: 36 kDa

Gene ID: 443

NCBI Accession: NM_000049, NP_000040

UniProt: P45381