PPP2R2D antibody (C-Term)

Catalog No. ABIN2786544

Product Details anti-PPP2R2D Antibody

Target: PPP2R2D (Protein Phosphatase 2, Regulatory Subunit B, delta (PPP2R2D))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Guinea Pig, Horse, Cow, Dog, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP2R2D antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RRDVTLEASR ENSKPRASLK PRKVCTGGKR KKDEISVDSL DFNKKILHTA

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against Ppp2r2d. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 453 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PPP2R2D

Target: PPP2R2D (Protein Phosphatase 2, Regulatory Subunit B, delta (PPP2R2D))

Alternative Name: Ppp2r2d (PPP2R2D Products)

Synonyms: 1300017E19Rik antibody, D7Ertd753e antibody, MDS026 antibody, protein phosphatase 2, regulatory subunit B, delta antibody, protein phosphatase 2 regulatory subunit Bdelta antibody, protein phosphatase 2 regulatory subunit B, delta S homeolog antibody, Ppp2r2d antibody, PPP2R2D antibody, ppp2r2d.S antibody

Background: Ppp2r2d is a B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment.
Alias Symbols: 1300017E19Rik, D7Ertd753e, MDS026
Protein Interaction Partner: Supt5, SMURF1, SMAD3, SMAD2,
Protein Size: 453

Molecular Weight: 50 kDa

Gene ID: 52432

NCBI Accession: NM_026391, NP_080667

UniProt: Q925E7