PPP2R2D antibody (Regulatory Subunit B)

Catalog No. ABIN7169250

Product Details anti-PPP2R2D Antibody

Target: PPP2R2D (Protein Phosphatase 2, Regulatory Subunit B, delta (PPP2R2D))

Binding Specificity: AA 1-192, Regulatory Subunit B

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP2R2D antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform protein (1-192AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PPP2R2D

Target: PPP2R2D (Protein Phosphatase 2, Regulatory Subunit B, delta (PPP2R2D))

Alternative Name: PPP2R2D (PPP2R2D Products)

Synonyms: 1300017E19Rik antibody, D7Ertd753e antibody, MDS026 antibody, protein phosphatase 2, regulatory subunit B, delta antibody, protein phosphatase 2 regulatory subunit Bdelta antibody, protein phosphatase 2 regulatory subunit B, delta S homeolog antibody, Ppp2r2d antibody, PPP2R2D antibody, ppp2r2d.S antibody

Background:

Background: B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).

Aliases: 2ABD_HUMAN antibody, MDS026 antibody, PP2A subunit B isoform B55-delta antibody, PP2A subunit B isoform delta antibody, PP2A subunit B isoform PR55-delta antibody, PP2A subunit B isoform R2-delta antibody, PPP2R2D antibody, Protein phosphatase 2 regulatory subunit B delta antibody, Protein phosphatase 2 regulatory subunit B delta isoform antibody, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform antibody

UniProt: Q66LE6