TPMT antibody (C-Term)

Catalog No. ABIN2789428

This Rabbit Polyclonal antibody specifically detects TPMT in WB. It exhibits reactivity toward Human, Dog and Pig.

Quick Overview for TPMT antibody (C-Term) (ABIN2789428)

Target: TPMT (Thiopurine S-Methyltransferase (TPMT))

Reactivity: Human, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TPMT antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TPMT Antibody

Binding Specificity: C-Term

Purpose: TPMT Antibody - C-terminal region

Sequence: RGALVAINPG DRKCYADTMF SLLGKKFQYL LCVLSYDPTK HPGPPFYVPH

Predicted Reactivity: Dog: 79%, Human: 100%, Pig: 79%

Characteristics: This is a rabbit polyclonal antibody against TPMT. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63262-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for TPMT

Target: TPMT (Thiopurine S-Methyltransferase (TPMT))

Alternative Name: TPMT

Background:

Background Information: This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.

Gene Name: Thiopurine S-methyltransferase

Alternative Symbols: TPMTD

Protein Name: Thiopurine S-methyltransferase

Molecular Weight: 27kDa

Gene ID: 7172

NCBI Accession: NP_000358

UniProt: P51580