IL1R1 antibody (C-Term)

Catalog No. ABIN2789664

The Rabbit Polyclonal anti-IL1R1 antibody is suitable to detect IL1R1 in samples from Human, Mouse, Rat, Dog, Horse, Guinea Pig and Rabbit. It has been validated for WB.

Quick Overview for IL1R1 antibody (C-Term) (ABIN2789664)

Target: IL1R1 (Interleukin 1 Receptor, Type I (IL1R1))

Reactivity: Human, Mouse, Rat, Dog, Horse, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL1R1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL1R1 Antibody

Binding Specificity: C-Term

Sequence: LELEKIQDYE KMPESIKFIK QKHGAIRWSG DFTQGPQSAK TRFWKNVRYH

Predicted Reactivity: Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against IL1R1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 569 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IL1R1

Target: IL1R1 (Interleukin 1 Receptor, Type I (IL1R1))

Alternative Name: IL1R1

Background: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
Alias Symbols: CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80
Protein Interaction Partner: TRAF6, IRAK1, IL1RAP, MYD88, HERPUD1, TICAM2, PELI1, IRAK2, MARCH8, IRAK4, TOLLIP, TOM1, UBC, IL1F10, SIGIRR, PIK3R1, IL1A, IL1B, IL1RN,
Protein Size: 569

Molecular Weight: 63 kDa

Gene ID: 3554

NCBI Accession: NM_000877, NP_000868

UniProt: P14778

Pathways: NF-kappaB Signaling, Carbohydrate Homeostasis, Cancer Immune Checkpoints