CRHR2 antibody (N-Term)

Catalog No. ABIN2789725

This Rabbit Polyclonal antibody specifically detects CRHR2 in WB. It exhibits reactivity toward Human, Rat, Mouse, Cow, Rabbit, Dog, Horse, Guinea Pig, Sheep and Zebrafish (Danio rerio).

Quick Overview for CRHR2 antibody (N-Term) (ABIN2789725)

Target: CRHR2 (Corticotropin Releasing Hormone Receptor 2 (CRHR2))

Reactivity: Human, Rat, Mouse, Cow, Rabbit, Dog, Horse, Guinea Pig, Sheep, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRHR2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CRHR2 Antibody

Binding Specificity: N-Term

Sequence: NTTLDQIGTC WPRSAAGALV ERPCPEYFNG VKYNTTRNAY RECLENGTWA

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%, Sheep: 75%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against CRHR2. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 438 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CRHR2

Target: CRHR2 (Corticotropin Releasing Hormone Receptor 2 (CRHR2))

Alternative Name: CRHR2

Background: The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis.
Alias Symbols: CRFR2, CRF2, CRF-RB, HM-CRF
Protein Interaction Partner: APP, UCN2, UCN3, CRH, CRHR2, UCN,
Protein Size: 438

Molecular Weight: 48 kDa

Gene ID: 1395

NCBI Accession: NM_001202475, NP_001189404

UniProt: Q13324

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Feeding Behaviour