FAK antibody (Middle Region)

Catalog No. ABIN2791666

The Rabbit Polyclonal anti-FAK antibody (ABIN2791666) specifically detects FAK in WB. The antibody is reactive with Human, Mouse, Rat, Zebrafish (Danio rerio), Dog, Cow, Rabbit, Horse and Guinea Pig samples.

Quick Overview for FAK antibody (Middle Region) (ABIN2791666)

Target: FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Dog, Cow, Rabbit, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAK antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FAK Antibody

Binding Specificity: Middle Region

Sequence: SEKQGMRTHA VSVSETDDYA EIIDEEDTYT MPSTRDYEIQ RER
IELGRC

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PTK2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human PTK2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FAK

Target: FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

Alternative Name: PTK2

Background: This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.
Protein Interaction Partner: DEF6, SOCS3, YES1, IQGAP1, UBE2H, UBC, TRIM72, SRPK1, PXN, PTRH2, SAE1, HSP90AA1, APP, RBSN, BCAR1, KCNJ3, PTAFR, STAT1, CBL, STAP2, STUB1, PTPN11, PPP1CB, PPP1CA, SRC, CTTN, ASAP1, SH3KBP1, PDCD6IP, ITGB5, ELAVL1, DAG1, GRB2, FBP1, F13A1, EEF1G, LPXN, TG
Protein Size: 431

Molecular Weight: 47 kDa

Gene ID: 5747

Pathways: Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling