ERK1 antibody (N-Term)

Catalog No. ABIN2792053

This Rabbit Polyclonal antibody specifically detects ERK1 in WB. It exhibits reactivity toward Human and Pig.

Quick Overview for ERK1 antibody (N-Term) (ABIN2792053)

Target: ERK1 (MAPK3) (Mitogen-Activated Protein Kinase 3 (MAPK3))

Reactivity: Human, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERK1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ERK1 Antibody

Binding Specificity: N-Term

Sequence: GGGGGEPRRT EGVGPGVPGE VEMVKGQPFD VGPRYTQLQY IGEGAYGMVS

Predicted Reactivity: Human: 100%, Pig: 79%

Characteristics: This is a rabbit polyclonal antibody against MAPK3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human MAPK3

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ERK1

Target: ERK1 (MAPK3) (Mitogen-Activated Protein Kinase 3 (MAPK3))

Alternative Name: MAPK3

Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
Protein Interaction Partner: MAPK1, DUSP4, STAR, RAF1, PTGDR, MAP2K1, NAB2, MYOG, DHPS, HDAC6, MAGED1, AMOT, FOXP2, CDC23, VPS52, L3MBTL3, TRIM54, DCP1A, UBC, TP53, PTGS2, RPS6KA2, MAPK3, PHF3, TEK, MBP, ELK1, CUEDC2, MAPKAPK2, GAB2, IRX2, ADAM15, VCP, ELK4, DAPK1, Rara, IQGAP1, TP53
Protein Size: 357

Molecular Weight: 39 kDa

Gene ID: 5595

Pathways: MAPK Signaling, RTK Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, S100 Proteins