SOCS6 antibody (N-Term)

Catalog No. ABIN2798439

Product Details anti-SOCS6 Antibody

Target: SOCS6 (Suppressor of Cytokine Signaling 6 (SOCS6))

Binding Specificity: AA 40-69, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purpose: Rabbit Anti-Human SOCS6 (N-term) Antibody

Immunogen: This SOCS6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-69 amino acids from the N-terminal region of human SOCS6.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50SOCS6 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for SOCS6

Target: SOCS6 (Suppressor of Cytokine Signaling 6 (SOCS6))

Alternative Name: SOCS6 (SOCS6 Products)

Synonyms: CIS-4 antibody, CIS4 antibody, HSPC060 antibody, SOCS-4 antibody, SOCS-6 antibody, SOCS4 antibody, SSI4 antibody, STAI4 antibody, STATI4 antibody, socs6 antibody, MGC81477 antibody, SOCS6 antibody, 1500012M23Rik antibody, 5830401B18Rik antibody, AI447482 antibody, Cis4 antibody, Cish4 antibody, Socs4 antibody, socs6l antibody, zgc:64107 antibody, wu:fb77f06 antibody, suppressor of cytokine signaling 6 antibody, suppressor of cytokine signaling 6 L homeolog antibody, suppressor of cytokine signaling antibody, suppressor of cytokine signaling 6b antibody, SOCS6 antibody, Socs6 antibody, socs6.L antibody, socs6 antibody, socs6b antibody

Background:

Target Description: The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.

Gene Symbol: SOCS6

Molecular Weight: 59528 Da

Gene ID: 9306

UniProt: O14544

Pathways: JAK-STAT Signaling, Carbohydrate Homeostasis