Cyclin D2 antibody

Catalog No. ABIN1944917

Product Details anti-Cyclin D2 Antibody

Target: Cyclin D2 (CCND2)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin D2 antibody is un-conjugated

Application: Western Blotting (WB)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Storage: 4 °C,-20 °C

References for anti-Cyclin D2 antibody (ABIN1944917)

Palmero, Holder, Sinclair, Dickson, Peters: "Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines." in: Oncogene, Vol. 8, Issue 4, pp. 1049-54, (1993) (PubMed).

Xiong, Menninger, Beach, Ward: "Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins." in: Genomics, Vol. 13, Issue 3, pp. 575-84, (1992) (PubMed).

Target Details for Cyclin D2

Target: Cyclin D2 (CCND2)

Alternative Name: Cyclin D2 (CCND2 Products)

Synonyms: si:ch211-240j22.2 antibody, ccnd2 antibody, CCND2 antibody, kiak0002 antibody, zgc:162280 antibody, LOC100224096 antibody, KIAK0002 antibody, BF642806 antibody, C86853 antibody, Vin-1 antibody, Vin1 antibody, cD2 antibody, 2600016F06Rik antibody, AI256817 antibody, cyclin D2, b antibody, cyclin D2 S homeolog antibody, cyclin D2 antibody, G1/S-specific cyclin-D2 antibody, cyclin D2, a antibody, cyclin D2 L homeolog antibody, ccnd2b antibody, ccnd2.S antibody, CCND2 antibody, ccnd2 antibody, ccnd2a antibody, Ccnd2 antibody, ccnd2.L antibody

Background: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

Molecular Weight: 33067 Da

Gene ID: 894

UniProt: P30279

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases