SIGMAR1 antibody (N-Term)

Catalog No. ABIN2839374

This Rabbit Polyclonal antibody specifically detects SIGMAR1 in WB and FACS. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for SIGMAR1 antibody (N-Term) (ABIN2839374)

Target: SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIGMAR1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: RB14256

Product Details anti-SIGMAR1 Antibody

Binding Specificity: AA 47-81, N-Term

Predicted Reactivity: M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This OPRS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-81 amino acids from the N-terminal region of human OPRS1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-SIGMAR1 antibody (ABIN2839374)

Gueguinou, Crottès, Chantôme, Rapetti-Mauss, Potier-Cartereau, Clarysse, Girault, Fourbon, Jézéquel, Guérin-Charbonnel, Fromont, Martin, Pellissier, Schiappa, Chamorey, Mignen, Uguen, Borgese et al.: "The SigmaR1 chaperone drives breast and colorectal cancer cell migration by tuning SK3-dependent Ca2+ homeostasis. ..." in: Oncogene, Vol. 36, Issue 25, pp. 3640-3647, (2017) (PubMed).

Target Details for SIGMAR1

Target: SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))

Alternative Name: OPRS1

Background: OPRS1 is a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems.

Molecular Weight: 25128

Gene ID: 10280

NCBI Accession: NP_001269134, NP_001269135, NP_001269136, NP_001269137, NP_001269138, NP_005857, NP_671513

UniProt: Q99720

Pathways: SARS-CoV-2 Protein Interactome