SIGMAR1 antibody (AA 21-120)

Catalog No. ABIN709841

The Rabbit Polyclonal anti-SIGMAR1 antibody is suitable to detect SIGMAR1 in samples from Human. It has been validated for WB, IHC (p), IF (cc), IF (p) and IHC (fro).

Quick Overview for SIGMAR1 antibody (AA 21-120) (ABIN709841)

Target: SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIGMAR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-SIGMAR1 Antibody

Binding Specificity: AA 21-120

Purpose: OPRS1 Polyclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human OPRS1

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SIGMAR1

Target: SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))

Alternative Name: OPRS1

Background:

Synonyms: SRBP, ALS16, OPRS1, SR-BP, SIG-1R, SR-BP1, sigma1R, hSigmaR1, Sigma non-opioid intracellular receptor 1, Aging-associated gene 8 protein, SR31747-binding protein, Sigma 1-type opioid receptor, Sigma1-receptor, SIGMAR1, AAG8

Background: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration.

Gene ID: 10280

UniProt: Q99720

Pathways: SARS-CoV-2 Protein Interactome