RUNX2 antibody (pSer465)

Catalog No. ABIN389942

Product Details anti-RUNX2 Antibody

Target: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Binding Specificity: pSer465

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RUNX2 antibody is un-conjugated

Application: Dot Blot (DB)

Specificity: This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S533 of human RUNX2.

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RUNX2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S465 of human RUNX2.

Clone: RB15321

Isotype: Ig Fraction

Application Details

Application Notes: DB = 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-RUNX2 antibody (ABIN389942)

Fu, Wang, Lu, Ma, Ke, Liu, Luo: "In vitro inhibitory effects of terpenoids from Chloranthus multistachys on epithelial-mesenchymal transition via down-regulation of Runx2 activation in human breast cancer." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 22, Issue 1, pp. 165-72, (2015) (PubMed).

Wang, Cai, Ma, Liu, Ke, Lu, Fu: "The natural compound codonolactone impairs tumor induced angiogenesis by downregulating BMP signaling in endothelial cells." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 22, Issue 11, pp. 1017-26, (2015) (PubMed).

Fu, Ke, Tan, Liu, Wang, Ma, Lu: "The natural compound codonolactone attenuates TGF-?1-mediated epithelial-to-mesenchymal transition and motility of breast cancer cells." in: Oncology reports, (2015) (PubMed).

Wang, Chen, Zou, Tu, Tan, Lu, Liu, Fu: "Codonolactone, a sesquiterpene lactone isolated from Chloranthus henryi Hemsl, inhibits breast cancer cell invasion, migration and metastasis by downregulating the transcriptional activity of Runx2." in: International journal of oncology, Vol. 45, Issue 5, pp. 1891-900, (2014) (PubMed).

Tsimbouri, Murawski, Hamilton, Herzyk, Oreffo, Gadegaard, Dalby: "A genomics approach in determining nanotopographical effects on MSC phenotype." in: Biomaterials, Vol. 34, Issue 9, pp. 2177-84, (2013) (PubMed).

Tsimbouri, McMurray, Burgess, Alakpa, Reynolds, Murawski, Kingham, Oreffo, Gadegaard, Dalby: "Using nanotopography and metabolomics to identify biochemical effectors of multipotency." in: ACS nano, Vol. 6, Issue 11, pp. 10239-49, (2012) (PubMed).

McNamara, Sjöström, Burgess, Kim, Liu, Gordonov, Moghe, Meek, Oreffo, Su, Dalby: "Skeletal stem cell physiology on functionally distinct titania nanotopographies." in: Biomaterials, Vol. 32, Issue 30, pp. 7403-10, (2011) (PubMed).

Tetsunaga, Nishida, Furumatsu, Naruse, Hirohata, Yoshida, Saito, Ozaki: "Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells." in: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, Vol. 19, Issue 2, pp. 222-32, (2011) (PubMed).

Target Details for RUNX2

Target: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Alternative Name: RUNX2 (RUNX2 Products)

Synonyms: AML3 antibody, CBF-alpha-1 antibody, CBFA1 antibody, CCD antibody, CCD1 antibody, CLCD antibody, OSF-2 antibody, OSF2 antibody, PEA2aA antibody, PEBP2aA antibody, Cbf antibody, Cbfa-1 antibody, Cbfa1 antibody, LS3 antibody, Osf2 antibody, Pebp2a1 antibody, Pebpa2a antibody, runx2 antibody, RUNX2 antibody, ccd antibody, aml3 antibody, ccd1 antibody, osf2 antibody, cbfa1 antibody, pea2aa antibody, pebp2a1 antibody, pebp2a2 antibody, pebp2aa antibody, pebp2aa1 antibody, runt related transcription factor 2 antibody, runt-related transcription factor 2a antibody, runt-related transcription factor 2 antibody, runt related transcription factor 2 L homeolog antibody, RUNX2 antibody, runx2a antibody, Runx2 antibody, runx2 antibody, LOC703331 antibody, LOC100549663 antibody, runx2.L antibody

Background: Synonyms: Runt-related transcription factor 2, Core-binding factor subunit alpha-1, CBF-alpha-1, Acute myeloid leukemia 3 protein, Oncogene AML-3, Polyomavirus enhancer-binding protein 2 alpha A subunit, PEBP2-alpha A, PEA2-alpha A, SL3-3 enhancer factor 1 alpha A

Molecular Weight: 56648 DA

Gene ID: 860

UniProt: Q13950