MME antibody (AA 272-300)

Catalog No. ABIN2843797

Product Details anti-MME Antibody

Target: MME (Membrane Metallo-Endopeptidase (MME))

Binding Specificity: AA 272-300

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MME antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.

Immunogen: This MME/CD10 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 272-300 amino acids from human MME/CD10.

Clone: 307CT12-12-5

Isotype: IgM kappa

Application Details

Application Notes: IHC: 1:1000. WB: 1:100~250

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: MME/CD10 Antibody can be refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for MME

Target: MME (Membrane Metallo-Endopeptidase (MME))

Alternative Name: MME/CD10 (MME Products)

Synonyms: CALLA antibody, CD10 antibody, NEP antibody, SFE antibody, 6030454K05Rik antibody, C85356 antibody, Nep antibody, neprilysin antibody, membrane metalloendopeptidase antibody, membrane metallo endopeptidase antibody, membrane metallo-endopeptidase antibody, MME antibody, Mme antibody

Target Type: Chemical

Background: This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85 % of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq].

Molecular Weight: 85514

Gene ID: 4311

NCBI Accession: NP_000893, NP_009218, NP_009219, NP_009220

UniProt: P08473

Pathways: RTK Signaling, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration