CYP3A7 antibody (Center)

Catalog No. ABIN2855738

Product Details anti-CYP3A7 Antibody

Target: CYP3A7 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 7 (CYP3A7))

Binding Specificity: Center

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP3A7 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Monkey

Cross-Reactivity (Details): Monkey (93 %)

Characteristics: Rabbit Polyclonal antibody to CYP3A7 (cytochrome P450, family 3, subfamily A, polypeptide 7)
CYP3A7 antibody [N3C3]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human CYP3A7. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: Suggested dilution Reference Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceWestern blot1:500-1:3000*

Comment:

Positive Control: A549 , HeLa , HepG2

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.8 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 20 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for CYP3A7

Target: CYP3A7 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 7 (CYP3A7))

Alternative Name: CYP3A7 (CYP3A7 Products)

Synonyms: CP37 antibody, CYPIIIA7 antibody, P450-HFLA antibody, cytochrome P450, family 3, subfamily A, polypeptide 7 antibody, cytochrome P450 family 3 subfamily A member 7 antibody, CYP3A7 antibody

Background: This gene, CYP3A7, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described, but it is not known whether these transcripts are normally produced.

Cellular Localization: Endoplasmic reticulum membrane , Microsome membrane

Molecular Weight: 58 kDa

Gene ID: 1551

Pathways: Steroid Hormone Biosynthesis