NUP62 antibody

Catalog No. ABIN2856548

Product Details anti-NUP62 Antibody

Target: NUP62 (Nucleoporin 62kDa (NUP62))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUP62 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Rabbit Polyclonal antibody to Nucleoporin p62 (nucleoporin 62 kDa)
Nucleoporin p62 antibody

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human Nucleoporin p62. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:1000-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: NIH-3T3 , JC , BCL-1 , C2C12 , PC-12 , HepG2

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-NUP62 antibody (ABIN2856548)

Rodriguez-Bravo, Pippa, Song, Carceles-Cordon, Dominguez-Andres, Fujiwara, Woo, Koh, Ertel, Lokareddy, Cuesta-Dominguez, Kim, Rodriguez-Fernandez, Li, Gordon, Hirschfield, Prats, Reddy, Fatatis et al.: "Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import. ..." in: Cell, Vol. 174, Issue 5, pp. 1200-1215.e20, (2019) (PubMed).

Target Details for NUP62

Target: NUP62 (Nucleoporin 62kDa (NUP62))

Alternative Name: nucleoporin 62 (NUP62 Products)

Synonyms: IBSN antibody, SNDI antibody, p62 antibody, NUP62 antibody, AA589433 antibody, AI426861 antibody, AI790512 antibody, AU045898 antibody, D7Ertd649e antibody, Nupc1 antibody, CG6251 antibody, Dmel\\CG6251 antibody, DDBDRAFT_0167902 antibody, DDBDRAFT_0237712 antibody, DDB_0167902 antibody, DDB_0237712 antibody, nup62 antibody, Np62 antibody, nucleoporin 62 antibody, hypothetical protein antibody, nucleoporin 62kDa antibody, Nucleoporin 62kD antibody, predicted protein antibody, nuclear pore protein antibody, Nup62 nuclear pore complex glycoprotein p62-related protein (IC) antibody, Nuclear pore glycoprotein p62 antibody, NUP62 antibody, PGTG_03077 antibody, Nup62 antibody, nup62 antibody

Background: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform.

Cellular Localization: Nucleus , nuclear pore complex

Molecular Weight: 53 kDa

Gene ID: 23636

UniProt: P37198

Pathways: EGFR Signaling Pathway, SARS-CoV-2 Protein Interactome