Angiotensin II Type-1 Receptor antibody

Catalog No. ABIN289368

Product Details anti-Angiotensin II Type-1 Receptor Antibody

Target: Angiotensin II Type-1 Receptor (AGTR1) (Angiotensin II Receptor, Type 1 (AGTR1))

Reactivity: Rat

Host: Chicken

Clonality: Polyclonal

Conjugate: This Angiotensin II Type-1 Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Specificity: The 10 aa peptide is 100%, identical in Mouse, Ovine rat, human, Pig,and rabbit.

Cross-Reactivity (Details): This 10 AA immunogenic peptide is 100 % identical in mouse, rat, human, ovine, pig, dog, chimpanzee and chicken. The sequence is the same in all AT II receptor isoforms (Type 1a, 1b, and 1c).

Purification: Affinity chromatography purified

Immunogen: AGTR1 antibody was raised in chicken using 10-aa peptide from rat AT-II type 1 as the immunogen.

Isotype: IgG

Application Details

Application Notes: ELISA: 1:10,000-1:100,000, WB: 1-10 µg/mL
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in PBS to a concentration of 1 mg/mL

Concentration: Lot specific

Buffer: Lyophilized from PBS with 0.1 % BSA.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.

References for anti-Angiotensin II Type-1 Receptor antibody (ABIN289368)

Walch, Carreño, Cunningham: "Intracerebroventricular losartan infusion modulates angiotensin II type 1 receptor expression in the subfornical organ and drinking behaviour in bile-duct-ligated rats." in: Experimental physiology, Vol. 98, Issue 4, pp. 922-33, (2013) (PubMed).

Target Details for Angiotensin II Type-1 Receptor

Target: Angiotensin II Type-1 Receptor (AGTR1) (Angiotensin II Receptor, Type 1 (AGTR1))

Alternative Name: AGTR1 (AGTR1 Products)

Synonyms: AG2S antibody, AGTR1A antibody, AGTR1B antibody, AT1 antibody, AT1AR antibody, AT1B antibody, AT1BR antibody, AT1R antibody, AT2R1 antibody, AT2R1A antibody, AT2R1B antibody, HAT1R antibody, 1810074K20Rik antibody, AI551199 antibody, AT1a antibody, Agtr-1a antibody, Agtr1 antibody, Angtr-1a antibody, AT1A antibody, XAT-1 antibody, agtr1-A antibody, agtr1.2 antibody, AT1-R antibody, at1 antibody, AGTR1 antibody, Agtr-1b antibody, Angtr-1b antibody, agtr1 antibody, agtr1-a antibody, agtr1-b antibody, xAT antibody, angiotensin II receptor type 1 antibody, angiotensin II receptor, type 1a antibody, angiotensin II receptor type 1 S homeolog antibody, uncharacterized AGTR1 antibody, angiotensin II receptor, type 1b antibody, angiotensin II receptor type 1 L homeolog antibody, AGTR1 antibody, Agtr1a antibody, agtr1.S antibody, Agtr1 antibody, Agtr1b antibody, agtr1.L antibody

Background: Angiotensin II receptor, type 1 or AT1 receptor is an angiotensin receptor. It has vasopressor effects and regulates aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. Angiotensin II receptor antagonists are drugs indicated for hypertension, diabetic nephropathy and congestive heart failure.

Pathways: JAK-STAT Signaling, ACE Inhibitor Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour