Oncostatin M antibody

Catalog No. ABIN289518

Product Details anti-Oncostatin M Antibody

Target: Oncostatin M (OSM)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Oncostatin M antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Blocking Antibody (Inhibition)

Purification: Purified

Immunogen: Oncostatin M antibody was raised in rabbit using highly pure recombinant human oncostatin M as the immunogen.

Application Details

Application Notes: ELISA: 0.5-2 µg/mL, Inhibition: 0.1-0.175 µg/mL, WB: 0.1-0.2 µg/mL
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in sterile water to a concentration of > 0.2 mg/mL.

Concentration: Lot specific

Buffer: Lyophilized from 0.5 x PBS, pH 7.4.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.

Target Details for Oncostatin M

Target: Oncostatin M (OSM)

Alternative Name: Oncostatin M (OSM Products)

Synonyms: OSM antibody, OncoM antibody, oncostatin M antibody, OSM antibody, Osm antibody

Background: Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activate T cells, monocytes and Kaposi’s sarcoma cells, OSH can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL6, and CNTF. Human OSM is active on Mouse cells.

Molecular Weight: 23.9 kDa (predicted detection band MW)

Pathways: JAK-STAT Signaling, Negative Regulation of Hormone Secretion