NR1I2 antibody (AA 100-200)

Catalog No. ABIN3015525

Product Details anti-NR1I2 Antibody

Target: NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))

Binding Specificity: AA 100-200

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR1I2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: CKGFFRRAMK RNARLRCPFR KGACEITRKT RRQCQACRLR KCLESGMKKE MIMSDEAVEE RRALIKRKKS ERTGTQPLGV QGLTEEQRMM IRELMDAQMK T

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human PXR (NP_071285.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NR1I2

Target: NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))

Alternative Name: NR1I2 (NR1I2 Products)

Synonyms: BXR antibody, ONR1 antibody, PAR antibody, PAR1 antibody, PAR2 antibody, PARq antibody, PRR antibody, PXR antibody, SAR antibody, SXR antibody, PXR.1 antibody, PXR.2 antibody, PXR1 antibody, mPXR antibody, bxr antibody, nr1i2 antibody, onr1 antibody, xonr1 antibody, nuclear receptor subfamily 1 group I member 2 antibody, nuclear receptor subfamily 1, group I, member 2 antibody, nuclear receptor subfamily 1 group I member 2 S homeolog antibody, NR1I2 antibody, Nr1i2 antibody, nr1i2.S antibody, nr1i2 antibody

Background: This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.,NR1I2,BXR,ONR1,PAR,PAR1,PAR2,PARq,PRR,PXR,SAR,SXR,Epigenetics & Nuclear Signaling,Transcription Factors,Nuclear Receptor Signaling,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Endocrine & Metabolism,Drug metabolism,NR1I2

Molecular Weight: 39 kDa/43 kDa/45 kDa/48 kDa/49 kDa/52 kDa/53 kDa

Gene ID: 8856

UniProt: O75469

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway