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DcR1 antibody
TNFRSF10C
Reactivity: Human
FACS
Host: Mouse
Monoclonal
TRAIL-R3-02
unconjugated
Product Details anti-DcR1 Antibody
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Target
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DcR1 (TNFRSF10C)
(Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))
Reactivity
All reactivities for DcR1 antibodies
Human
Host
All hosts for DcR1 antibodies
Mouse
Clonality
All clonalities for DcR1 antibodies
Monoclonal
Conjugate
All conjugates for DcR1 antibodies
This DcR1 antibody is un-conjugated
Application
All applications for DcR1 antibodies
Flow Cytometry (FACS)
Specificity
The antibody TRAIL-R3-02 reacts with TRAIL-R3, a 35 kDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils.
Cross-Reactivity (Details)
Human
Purification
Purified by protein-A affinity chromatography.
Purity
> 95 % (by SDS-PAGE)
Immunogen
TRAIL-R3-hIgGhc fusion protein
Clone
TRAIL-R3-02
Isotype
IgG1
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Discover our top product TNFRSF10C Primary Antibody
Alternatives
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Application Details
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Application Notes
Flow cytometry: Recommended dilution: 1-4 μg/mL.
Restrictions
For Research Use only
Handling
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Concentration
1 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.4
Preservative
Azide free
Handling Advice
Do not freeze.
Storage
4 °C
Storage Comment
Store at 2-8°C. Do not freeze.
Target Details for DcR1
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Target
DcR1 (TNFRSF10C)
(Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))
Alternative Name
CD263 / TRAIL-R3 (TNFRSF10C Products )
Synonyms
CD263 antibody, DCR1 antibody, DCR1-TNFR antibody, LIT antibody, TRAIL-R3 antibody, TRAILR3 antibody, TRID antibody, TNFRSF10C antibody, TNF receptor superfamily member 10c antibody, TNFRSF10C antibody
Background
TNF receptor superfamily member 10c,TRAIL-R3 (CD263, TR3, DcR1, LIT, TRID), expressed mainly on neutrophils, belongs to receptors of TRAIL, a TNF-like membrane cytotoxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R3, however, is a GPI-anchored protein that lacks cytoplasmic death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by competing for binding of TRAIL with death receptor 5 (DR5).,TNFRSF10C, DcR1, TRAIL-R3, TRID, LIT
Gene ID
8794
UniProt
O14798
Pathways
Apoptosis
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