Myocilin (MYOC) antibody

Details for Product No. ABIN3022197, Supplier: Log in to see
Antigen
  • MYOC
  • MGC136645
  • zgc:136645
  • AI957332
  • GLC1A
  • TIGR
  • GPOA
  • JOAG
  • JOAG1
  • myocilin
  • Tigr
  • myocilin
  • MYOC
  • myoc
  • Myoc
Reactivity
Mouse (Murine), Rat (Rattus), Human
58
23
22
9
2
1
Host
Rabbit
44
14
Clonality
Polyclonal
Conjugate
Un-conjugated
5
5
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
50
34
26
15
10
9
9
9
3
2
2
2
1
Options
Supplier
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Immunogen Recombinant protein of human MYOC
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name MYOC (MYOC Antibody Abstract)
Background Myocilin (MYOC), also known as TIGR or GLC1A, is a secreted glycoprotein of the olfactomedin family, originally identified in trabecular meshwork cells after prolonged treatment with glucocorticoids, and, independently, in the retina : 9176893, 9169133). It may participate in the obstruction of fluid outflow in the trabecular meshwork. Defects in MYOC are the cause of primary open angle glaucoma (POAG) : 21709622). MYOC has a molecular weight of 55-57 kDa, besides, a 66-kDa form, which could be a result of post-translational modifications, has also been reported in some researches : 9497363, 12150989).
Synonyms: GPOA, JOAG, TIGR, GLC1A, JOAG1, myocilin
Gene ID 4653
UniProt Q99972
Application Notes Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze / thaw cycles
Storage -20 °C/-80 °C
Supplier Images
Western Blotting (WB) image for anti-Myocilin (MYOC) antibody (ABIN3022197) anti-Myocilin (MYOC) antibody
Western Blotting (WB) image for anti-Myocilin (MYOC) antibody (ABIN3022197) Western blot analysis of extracts of various cell lines, using MYOC antibody.
Background publications Menaa, Braghini, Vasconcellos, Menaa, Costa, Figueiredo, Melo: "Keeping an eye on myocilin: a complex molecule associated with primary open-angle glaucoma susceptibility." in: Molecules (Basel, Switzerland), Vol. 16, Issue 7, pp. 5402-21, 2011 (PubMed).

Tamm: "Myocilin and glaucoma: facts and ideas." in: Progress in retinal and eye research, Vol. 21, Issue 4, pp. 395-428, 2002 (PubMed).

Nguyen, Chen, Huang, Chen, Johnson, Polansky: "Gene structure and properties of TIGR, an olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells." in: The Journal of biological chemistry, Vol. 273, Issue 11, pp. 6341-50, 1998 (PubMed).

Polansky, Fauss, Chen, Chen, Lütjen-Drecoll, Johnson, Kurtz, Ma, Bloom, Nguyen: "Cellular pharmacology and molecular biology of the trabecular meshwork inducible glucocorticoid response gene product." in: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde, Vol. 211, Issue 3, pp. 126-39, 1997 (PubMed).

Kubota, Noda, Wang, Minoshima, Asakawa, Kudoh, Mashima, Oguchi, Shimizu: "A novel myosin-like protein (myocilin) expressed in the connecting cilium of the photoreceptor: molecular cloning, tissue expression, and chromosomal mapping." in: Genomics, Vol. 41, Issue 3, pp. 360-9, 1997 (PubMed).

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