Integrin beta 2 antibody (AA 70-170)

Catalog No. ABIN3023118

This anti-Integrin beta 2 antibody is a Rabbit Polyclonal antibody detecting Integrin beta 2 in WB and IHC. Suitable for Human.

Quick Overview for Integrin beta 2 antibody (AA 70-170) (ABIN3023118)

Target: Integrin beta 2 (ITGB2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Integrin beta 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Integrin beta 2 Antibody

Binding Specificity: AA 70-170

Sequence: MRGCAADDIM DPTSLAETQE DHNGGQKQLS PQKVTLYLRP GQAAAFNVTF RRAKGYPIDL YYLMDLSYSM LDDLRNVKKL GGDLLRALNE ITESGRIGFG S

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 70-170 of human CD18 (NP_000202.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Integrin beta 2

Target: Integrin beta 2 (ITGB2)

Alternative Name: ITGB2

Background: This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants.,CD18,LAD,LCAMB,LFA-1,MAC-1,MF17,MFI7,ITGB2,Signal Transduction,G protein signaling,G2/M DNA Damage Checkpoint,PI3K-Akt Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Immunology & Inflammation,CD markers,T Cell Receptor Signaling Pathway,Stem Cells,Hematopoietic Progenitors,ITGB2

Molecular Weight: 84 kDa

Gene ID: 3689

UniProt: P05107

Pathways: NF-kappaB Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation