LAMP3 antibody

Catalog No. ABIN3023874

Product Details anti-LAMP3 Antibody

Target: LAMP3 (Lysosomal-Associated Membrane Protein 3 (LAMP3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LAMP3 antibody is un-conjugated

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Characteristics: This mAb recognizes protein of 26 kDa-60 kDa, which is identified as CD63/LAMP3. Its epitope is different from that of mAb LAMP3/803 or LAMP3/968 or NKI/C3 or MX-49.129.5. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63/LAMP3 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. It is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63/LAMP3 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. Deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.

Purification: Protein G affinity chromatography

Immunogen: Recombinant human protein was used as the immunogen for the LAMP3 antibody.

Clone: LAMP3-529

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal dilution of the LAMP3 antibody should be determined by the researcher.\. Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the LAMP3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for LAMP3

Target: LAMP3 (Lysosomal-Associated Membrane Protein 3 (LAMP3))

Alternative Name: LAMP3 (LAMP3 Products)

Synonyms: DC-LAMP antibody, CD208 antibody, DC LAMP antibody, DCLAMP antibody, LAMP antibody, LAMP-3 antibody, TSC403 antibody, 1200002D17Rik antibody, Cd208 antibody, lysosomal associated membrane protein 3 antibody, lysosomal-associated membrane protein 3 antibody, LAMP3 antibody, Lamp3 antibody

Background: This mAb recognizes protein of 26  kDa-60  kDa, which is identified as CD63/LAMP3. Its epitope is different from that of mAb LAMP3/803 or LAMP3/968 or NKI/C3 or MX-49.129.5. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63/LAMP3 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. It is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63/LAMP3 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. Deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.