AIMP1 antibody (C-Term)

Catalog No. ABIN3024741

Product Details anti-AIMP1 Antibody

Target: AIMP1 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1 (AIMP1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AIMP1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Protein A purified antibody

Immunogen: A recombinant protein fragment from the C-terminal region of human EMAP II was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.\. Western blot: 2-5 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: 0.5 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for AIMP1

Target: AIMP1 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1 (AIMP1))

Alternative Name: EMAP II (AIMP1 Products)

Synonyms: EMAP2 antibody, EMAPII antibody, HLD3 antibody, SCYE1 antibody, p43 antibody, wu:fa95a05 antibody, zgc:154081 antibody, AIMP1 antibody, 9830137A06Rik antibody, AIMP1/p43 antibody, Emap2 antibody, Scye1 antibody, scye1 antibody, aminoacyl tRNA synthetase complex interacting multifunctional protein 1 antibody, aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 antibody, aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 S homeolog antibody, AIMP1 antibody, aimp1 antibody, Aimp1 antibody, aimp1.S antibody

Background: EMAP II (Endothelial monocyte-activating polypeptide 2) is a pro-inflammatory cytokine and participant in apoptotic cell death. It is synthesized as a precursor (pro-EMAP II), lacking a secretion signal peptide. In apoptotic cells, the ~34 kDa pro-form of EMAP II is cleaved by Caspase-7 (and Caspase-3 to a lesser extent) at aspartate 144 to its mature, ~20 kDa form. The mature form of EMAP II has been found to have many different functions. In vivo, it recruits leukocytes to the site of apoptotic cell death. In vitro it has been shown to activate endothelial cells (and the release of von Willebrand factor, E-selectin and P-selectin), neutrophils, and induces macrophage expression of TNFa and TF (tissue factor). EMAP II is also a possible biomarker for brain injury, having been found to be differentially expressed in two types: traumatic injury shows an increase and ischemic injury shows a decrease in EMAP II expression (Dave, et al, 2014).

Gene ID: 9255